A boy who likes to skate and a girl who likes hats become friends, despite their differences.

Ms. Frizzle takes her class on a fieldtrip to a beehive in her magic school bus.

When Arnold, one of Ms. Frizzle's students, finds a small foxlike animal with huge ears in the lost and found, he and the rest of the class join in the search for the animal's habitat. They visit six different habitats: the Arctic, the North American temperate forest, the African grasslands, the Amazon rain forest, wetlands, and desert.