"Boston Detective Jane Rizzoli is on the case of a big game hunter found dead in his apartment, alone with the body of a beautiful white snow leopard he had recently been commissioned to procure and stuff for a high-profile museum in the area. Medical examiner Maura Isles connects the case to a number of seemingly unrelated deaths where the victims have all been found hanging upside down, the hallmark of a leopard's kill. Rizzoli follows the puzzling...

When an explosive misstep drives a painful wedge between Boston's finest crime-solving colleagues, Jane and Maura must set aside their personal difficulties in order to keep on top of the city's most heinous murder cases. Yet analyzing corpses and tracking killers is child's play compared to the complications that arise from both friends' families. Using intellect and instinct, the best friends do what it takes to regain each other2s trust while busting...

Best friends Jane Rizzoli and Dr. Maura Isles, a detective and a medical examiner, work together to solve homicides.