Since she was little, it's been drilled into Amy's head by her dad that monogamy isn't realistic. Now a magazine writer, Amy lives by that credo; enjoying what she feels is an uninhibited life free from stifling, boring romantic commitment, but in actuality, she's kind of in a rut. When she finds herself starting to fall for the subject of the new article she's writing, a charming and successful sports doctor named Aaron Conners; Amy starts to wonder...

Now at the head of his own company as an inventor, former security guard Larry Daley travels to the Smithsonian to rescue his old exhibit friends from storage, and stop an evil pharaoh from raising an army to take over the world.