Based on the final outline of Frank Herbert this book answers the question left by his final novel. Fugitives fleeing a mysterious enemy fly into the uncharted galaxy, using genetic technology they revive key figures from Dune's past to strengthen their forces.

Navigators, mutated by spice into beings far superior to normal humans, have made space travel possible: their prescient awareness allows them to foresee safe paths through the universe as starships "fold" space. Only one man knows the secret of creating Navigators, and he intends to use them to build a commercial empire that spans the galaxy. However, Josef Venport is embattled by antitechnology fanatics led by charismatic and dangerous Manford Torondo....