Based on the famous radio money giveaway show of the same name. James Stewart's uncle hates big band music, but Stewart manages to give Horace Heidt's band their "big break" by getting them on Uncle's radio program.

A zany red-head and her mother bring back a bogus butler to frontier New Mexico.

An IRS investigator comes to check on an unpredictable businessman who hasn't paid his taxes, and ends up falling in love with the man's pretty daughter.

As Destry, a mild-mannered deputy who doesn't like guns, Stewart is called to restore order to the hopelessly corrupt frontier town of Bottleneck. Though reluctant to undertake such an enormous task, he's soon roped into action after meeting the seductive Frenchy (Dietrich), an alluring saloon girl who belts out unforgettable show-stoppers like "The Boys in the Back Room," while winning the hero's heart.