In the early eighteenth century, two noble women compete with each other for the position of Queen Anne's intimate companion and confidante.

Through comic mayhem that stretches from the White House and through the heartland, Columbus, Tallahasse, Wichita, and Little Rock must face off against the many new kinds of zombies that have evolved since the first movie, as well as some new human survivors. But most of all, they have to face the growing pains of their own snarky, makeshift family.

Philosophy professor Abe Lucas is at rock bottom emotionally, unable to find any meaning or joy in life. He feels that everything he's tried to do from political activism to teaching hasn't made any difference. Abe gets involved with two women: Rita Richards, a lonely professor who is unhappy in her marriage; and Jill Pollard, his best student, who becomes his closest friend. Pure chance changes everything when Abe and Jill overhear a stranger's conversation...