Ragweed, a young country mouse, leaves his family and travels to the big city, where he finds excitement and danger and sees cats for the first time.

Poppy, accompanied by her troublesome son Junior, his skunk friend, and Uncle Ereth the porcupine, responds to a summons to return to her ancestral home, Gray House, to save the mice there from destruction by a bulldozer.

An adventure seeking Ragweed reluctantly helps an innocent but mischievous baby raccoon reunite with his mother and rescues a deer mouse trapped inside a cage.