"Mrs. Piggle-Wiggle has left her Upside-Down House and the animals that live there in the care of her twenty-something niece, Missy. Luckily for the town's families, Missy Piggle-Wiggle is capable of concocting the same sort of inventive cures for bad behavior that made her aunt an indispensable community resource"--

Even though she, her upside-down house, and its animal occupants are under quarantine with the Winter Effluvia, Missy Piggle-Wiggle manages to dispense cures to the misbehaving children of Little Spring Valley.