One Saturday night in Las Vegas, twelve-year-old Newell Ewing goes out with a friend and doesn't come home. In the aftermath of his disappearance, his mother, Lorraine, makes daily pilgrimages to her son's room and tortures herself with memories. Equally distraught, the boy's father, Lincoln, finds himself wanting to comfort his wife even as he yearns for solace, a loving touch, any kind of intimacy. As the Ewings navigate the mystery of what's become of their son, the circumstances surrounding Newell's vanishing and other events on that same night reverberate through the lives of seemingly disconnected strangers: a comic book illustrator in town for a weekend of debauchery; a painfully shy and possibly disturbed young artist; a stripper who imagines moments from her life as if they were movie scenes; a bubbly teenage wiccan anarchist; a dangerous and scheming gutter punk; a band of misfit runaways.