When disgraced doctor Daisuke Ido finds the detached head of a cyborg woman who has no memories, he names her Alita and attaches the head to a powerful new body that allows the reborn cyborg to track down those who prey on the weak.

Carmen and Juni Cortez are back. Now they are full-fledged SPYkid operatives with the OSS. Together they embark on a mission to a mysterious island to retreive a valuable device, which in the wrong hands could jeopardize the world!